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2 edition of study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. found in the catalog.

study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures.

Niels Kaj Jerne

study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures.

by Niels Kaj Jerne

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Published by [Munksgaard] in Copenhagen .
Written in English


Edition Notes

SeriesActa pathologica et microbiologica scandinavica. Supplementum, 87
Classifications
LC ClassificationsQR201.D5 J4
The Physical Object
Pagination183 p.
Number of Pages183
ID Numbers
Open LibraryOL201339M
LC Control Numbera 52001147
OCLC/WorldCa14670627

A study of avidity based on rabbit skin responses to diphtheria toxin-antioxin mixtures, N.K. Jerne; the natural-selection theory of antibody formation, N.K. Jerne; immunological speculations, N.K. Jerne; plaque formation in agar by single antibody-producing cells, N.K. Jerne and A.A. Nordin; the natural selection theory of antibody formation.   Whilst the evidence for affinity maturation was originally based on an analysis of the serum antibody elicited following immunization, the development of monoclonal antibodies has allowed a more detailed study of the antigen binding properties of the antibodies produced by individual B lymphocytes selected during an ongoing immune response.

(). A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. (). Antigen initiated B lymphocyte differentiations. IV. The adherence properties and response kinetics of antibody-forming cell progenitors from primed and unprimed mice. (). We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (K d) of nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73, IU/g. This could be used as a therapeutic drug against DT in .

JERNE NK. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acta Pathol Microbiol Scand Suppl. ; – [Google Scholar] Jones RJ, Jackson DM, Lowbury EJ. Antiserum and antibiotic in the prophylaxis of burns against Pseudomonas aeruginosa. Br J Plast Surg. Jan; 19 (1)– In he published his dissertation "A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures," which conferred on him the title Doctor of Medicine. Jerne's subsequent career was defined by three major dissertations: The first ground-breaking dissertation appeared in


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Study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures by Niels Kaj Jerne Download PDF EPUB FB2

Acta Pathol Microbiol Scand Suppl. ; A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin by: A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures Hardcover – January 1, by N.

Jerne (Author) See all Author: N. Jerne. A Study of Avidity based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures. As an example the log.

of toxin concentration corresponding to a given diameter of skin reaction in the rabbit was based on 1, observations carried out, This of course has long been recognized and described under the term "avidity" of : N.

Jerne. Genre/Form: Academic theses: Additional Physical Format: Online version: Jerne, Niels Kaj. Study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures by Niels Kaj Jerne With increasing epidemiological studies it became apparent that the neural manifestations of the disease are very uncommon, confined only to a small percentage of individuals of the most susceptible species.

A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Vilken kamp för att undslippa. Selected Co-authors Countries and Regions of Publication (8. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures.

JERNE NK Acta Pathol Microbiol Scand Suppl,01 Jan JERNE NK. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acta Pathol Microbiol Scand Suppl.

; – KOLB RW, BRANHAM SE, RIGGS DB. Comparison of the guinea pig and chick in evaluation of diphtheria toxin for the Schick test. Appl Microbiol. Jul; 3 (4)– [PMC free article]. Two diphtheria toxoid preparations were compared in potency assays in guinea-pigs using different methods for evaluation of the responses to vaccinati.

Jerne, N.K. (19S I) A study of avidity based on the rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acta Pathol. Microbiol. Stand. 87 (suppl.), l. N.K. JerneA study of avidity based on the rabbit skin responses to diphtheria toxin-antitoxin mixtures.

Study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures February Acta pathologica et microbiologica Scandinavica.

Supplementum. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acts Pathol. Microbiol. Scand.87Suppl., 17 Simonsen, O., Kjeldsen, K., Bentzon, M.W.

and Heron, I. Susceptibility to diphtheria in populations vaccinated before and Vaccine Volume 14 Number 13 Comparison of different vaccine. We isolated a human monoclonal antibody against diphtheria toxin (DT).

It bound to fragment B with a binding activity (Kd) of nM. The neutralizing activity assayed by the rabbit skin test was.

JERNE NK. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acta Pathol Microbiol Scand Suppl. ; – JERNE NK, AVEGNO P. The development of the phage-inactivating properties of serum during the course of specific immunization of an animal: reversible and irreversible inactivation.

J Immunol. Author(s): Jerne,Niels Kaj Title(s): A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Country of Publication: Denmark Publisher: Copenhagen [Munksgaard] The development of the avidity of 19S and 7S neutralizing antibodies was studied after the immunization of young rabbits with ΦX bacteriophage.

Both 19S and 7S antibodies formed during the entire course of the immunization process were able to neutralize bacteriophage ΦX without the participation of thermolabile serum components: neither heat inactivation at 56°C nor addition of.

Nevertheless, Jerne, in a classic PhD dissertation, concluded from “A study of avidity based on rabbit skin responses to diphtheria toxin–antitoxin mixtures” that the avidity differences all boiled down to differences in equilibrium constants for the reversible reaction between toxin (T) and antitoxin (A), that is, T + A TA.

The. Initiation and affinity maturation of the humoral immune response is driven by antigen interaction with BCR. To study how signaling and antigen presentation through BCR depend on antigen/BCR affinity, lysozyme-specific B cell transfectants were challenged with mutated lysozymes differing in their binding kinetics.

For detectable triggering, the antigen/BCR complex needed a Ka > M−1. for his thesis, A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures.[citation needed] From to Jerne was a Archaea (15, words) [view diff] exact match in snippet view article find links to article.

JERNE NK. A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acta Pathol Microbiol Scand Suppl. ; – KEYZER JL. De organisatie van de vaccinaties. Maandschr Kindergeneeskd. Nov; 23 (11)– LANSBERG HP. Shock na toediening van, gezuiverd serum.

Ned Tijdschr Geneeskd. (). A study of avidity based on rabbit skin responses to diphtheria toxin antitoxin mixtures. Acta Path. (). Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology.

(). Antigen-specific development of primary and memory T cells in vivo. ().A study of avidity: based on rabbit skin responses to diphtheria toxin–antitoxin mixtures. Acta Pathol. Microbiol. Scand. ; Google Scholar (DT).

Under normal circumstances, affinity maturation requires the formation of specialized structures called germinal centres (GCs) within the B-cell follicles of secondary lymphoid tissue.Four years later, he was awarded the doctorate for his thesis, A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures.[citation CD (1, words) [view diff] exact match in snippet view article find links to article.